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Illuminate hc11/23/2023 Researchers noted that differing brain regions fired almost perfectly in sync, with minuscule delays often less than 1 millisecond. Halje and his team found that despite interacting with different types of neural receptors, both 5-HT2AR psychedelics like LSD and NMDAR psychedelics like ketamine-induced remarkably similar repetitive patterns of high-frequency electrical activity in the brain. “When we gave the rats the psychedelic substances LSD and ketamine, the waves were clearly registered.”Įxamining the results, Dr. “For several of these areas, it is the first time anyone has successfully shown how individual neurons are affected by LSD in awake animals,” Dr. ![]() ![]() An amphetamine was also included as a non-psychedelic psychoactive control. The lab rats were then administered different psychedelic substances, including LSD, DOI, ketamine, and PCP (phencyclidine). The novel array allowed researchers to monitor local field potentials (LFPs)-signals generated by thousands of neurons-and single unit activities, which are the firing patterns of individual neurons. Researchers developed a state-of-the-art microelectrode array that simultaneously monitored the electrical activity in 128 regions of the rat’s brain. “I think that psychedelics is a great tool to study the neural basis of consciousness in laboratory animals since we share most of the same neural ‘hardware’ with other mammals,” Dr. Laboratory rats are frequently used in medical research because virtually all disease-linked human genes can be found in rats, and their brain structure closely resembles the human brain. Pär Halje at Lund University, the study used nine Sprague-Dawley rats to explore how substances like LSD, ketamine, and DOI (2,5-dimethoxy-4-iodoamphetamine) affect electrical brain activity. Despite their historical notoriety, only in the last decade or so have scientists been able to peek under the hood to understand what’s going on in the brain during a mind-altering experience. ![]() Humans have been captivated by altered states of consciousness for centuries, often induced by psychedelic substances. The study, published in Communication Biology, gives an unprecedented glimpse at the brain’s ‘symphony’ of neural activity during psychedelic experiences, potentially paving the way for a better understanding of human consciousness or new avenues for treating mental health disorders. A groundbreaking study by Lund University in Sweden has found that psychoactive drugs like LSD and ketamine can induce psychedelic neural hypersynchrony or simultaneous high-frequency electrical waves in multiple brain regions.
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